Statistically significant differences were observed between the HC and CRC groups in 22 indicators, including serum TC, TG, HDL-C, LDL-C, ApoA1, ApoA2, ApoB, ApoC2, ApoC3, CA, CDCA, DCA, GDCA, TDCA, LCA, GLCA, TLCA, UDCA, GUDCA, TUDCA, CA19-9, CEA. The gene discussed is APOC3; the disease is colorectal carcinoma.