Our data shows that the PI3K/AKT pathway contributes to inhibiting proliferation, inducing apoptosis, and blocking the cell cycle phase of the THP-1 cells line derived from AML-M5 treatment by wogonin, which is associated with the expression decreasing of CCND1/CDK2/CyclinA2 mRNA and AKT protein. This evidence concerns the gene CDK2 and acute myeloid leukemia.