Using network pharmacology in this work, the 141 potential therapeutic targets of wogonin on AML-M5 were obtained, and the PPI Network demonstrated the relationships between wogonin and AML-M5 represented by 71 nodes and linked with the edges involved eight core candidate target genes as following: HSP90AA1, PIK3R1, AKT1, CCND1, SRC, TP53, RELA and JUN. Here, PIK3R1 is linked to acute myeloid leukemia.