Given the importance of metabolic control and mTOR's role as a primary sensor and regulator of cellular energy, it is not surprising that this signaling is dysregulated in a variety of disease states like cancer and type 2 diabetes37,38 In the liver, muscle, and pancreatic islets of obese and high-fat-fed mice, mTOR activity is noticeably raised; this is associated to elevated pro-inflammatory cytokines, and nutrients like glucose39. This evidence concerns the gene MTOR and cancer.