We found the changes between normal adjacent and CRC tissues for HLA-A (02:01) and HLA-C (07:02) among class I alleles, and DPA1 (01:03, 02:01, 02:03, and 03:02), DPB1 (02:01, 04:01, 04:02, 05:01, and 104:01), DQA1 (01:01 and 01:02), DQB1 (03:01, 03:03, 04:01, 05:01, 05:03, and 06:02), and DRB1 (13:02) on class II alleles (Supplementary Fig. S12). Here, HLA-DPB1 is linked to colorectal carcinoma.