FOXM1 and cancer: Chemoresistance is a major barrier for the traditionally used anti-cancer drugs, while FOXM1 overexpression is closely associated with chemoresistance [3, 13, 14, 38] and poor survival in most solid tumors [6, 9]; whereas, FOXM1 down-regulation is proven very effective in restoring chemotherapy sensitivity in several human cancers [5, 37, 38].