FOXM1 is abnormally overexpressed and amplified in the majority of human cancers (such as ovarian cancer, colorectal cancer, esophageal cancer, breast cancer, prostate cancer, gastric cancer, and pancreatic cancer) [5–8] and well demonstrated as a master transcriptional regulator in cancer development [9, 10]. The gene discussed is FOXM1; the disease is esophageal cancer.