OTP and LMX1A are both transcription factors required for the development of dopaminergic neurons47; LMX1A is associated with Parkinson’s disease, and previous experiments have shown that the reduction of LMX1A and the closely related LMX1B negatively impacts dopaminergic neuron survival by increasing oxidative stress and generating mitochondrial DNA damage48. Here, LMX1A is linked to Parkinson disease.