Similarly, CircFGFR1 exerts immunosuppressive effects by sponging miR-381-3p, reducing CD8+ T cell infiltration [113], while hsa_circ_0003222, hsa_circ_0020714 and hsa_circ_0000190 promote proliferation, stemness, and anti-PD-1 therapeutic resistance in NSCLC [114–116]. This evidence concerns the gene CD8A and non-small cell lung carcinoma.