Identification of APC p.I1307K alone is unlikely to fully explain the phenotype of an individual fulfilling clinical testing criteria for testing of genes associated with colorectal cancer and polyposis, as outlined in the NHS Genomic Testing Directory, which broadly recommends testing in young onset or strong familial cases; thus, the clinical utility of reporting this variant as an isolated finding is uncertain. The gene discussed is APC; the disease is colorectal cancer.