PCSK9 and Hypercholesterolemia: VERVE-101 is a therapeutic LNP formulation for hypercholesterolaemia that provides excellent durable and potent inhibition of PCSK9 and long-lasting reductions in LDL cholesterol of over one year.126,127 This has been demonstrated in mice and non-human primates and has moved towards phase I trial testing (NCT05398029).