SCARB1 and neoplasm: PLPs were found to track to tumours in preclinical cancer models, detected using both fluorescence and PET imaging modalities, and enabled specific photodynamic therapy at the tumour site.90 Interestingly, SR-B1 is also highly expressed on atherosclerotic plaque macrophages where it mediates both the uptake and efflux of cholesterol, as well as anti-inflammatory pathways.100 The SR-B1-targeting capabilities of PLPs therefore suggest they will target plaque macrophages, promote cholesterol efflux, and exhibit anti-inflammatory effects.