LDLR and atherosclerosis: An example includes prednisolone-loaded liposomes (discussed in Section 4) that accumulated in plaque macrophages in patients but did not provide any anti-inflammatory or therapeutic effects and in patients with advanced atherosclerosis seemed to increase arterial wall inflammation.73 Further investigation in Ldlr−/− mice revealed that the liposomal formulation of the anti-inflammatory prednisolone had the paradoxical effect of increasing inflammatory cell infiltration in plaques and advanced the stage of atherosclerosis in these mice.