IL11 is a member of IL6 family whose classic receptor is gp130, a transmembrane glycoprotein.[44] At the physiological level, IL11 induces platelet maturation in macrophages and increases the platelet count, so IL11 treatment is a common clinical treatment for thrombocytopenia associated with chemotherapy and for promotion of platelet production. Here, IL6ST is linked to Thrombocytopenia.