Previous studies found that shear stress from intravascular flow activates integrin αVβ3 in ECs and in separate studies integrin αVβ3 has been shown to regulate PD‐L1 expression in cancer cells.[21, 22] Thus, we tested the possible role of integrin αVβ3 function in transmural flow‐induced PD‐L1 upregulation (Figure 4a). The gene discussed is CD274; the disease is cancer.