It has been validated that TNFAIP3 can restrict pyroptosis induced by NLRP3 inflammasome activation independent of its inhibitory effect on the NF‐κB pathway.[55, 56] In oral cavity, partial TNFAIP3 loss or impaired expression leads to increased gingival inflammation in oral mucosa.[57] Intriguingly, TNFAIP3 is constitutively expressed in gingival connective tissues: its expression is relatively low under healthy conditions and modestly upregulated in the gingival tissue of periodontitis patients,[58] indicating its sustainability may be altered by post‐transcriptional modification. Here, NFKB1 is linked to periodontitis.