Its dysregulation closely correlates with a variety of chronic low‐grade inflammations including periodontal diseases.[50, 51, 52, 53] From a clinical aspect, NLRP3 inflammasome‐related proteins are also shown to have a positive association with the severity of periodontal lesions, and relevant markers are suggested as the indicators for periodontal prognosis.[50] Genetic deletion of Nlrp3 or drug inhibition of NLRP3 inflammasome formation could alleviate the progression of periodontitis in mice.[54]. The gene discussed is NLRP3; the disease is periodontitis.