Since we demonstrated that early-emerging CVB-5’TD forms modulate IFN-β signaling pathway activation, we studied the impact of Poly(I:C), a synthetic dsRNA known to induce type I IFN response through TLR3 (Toll-like-receptors 3) and RLR, on CVB3/28-induced myocarditis in DBA/2J mice (Fig 5). Here, DHX58 is linked to myocarditis.