By contrast, neutrophils from patients with CGD caused by genetic deficiency of any of the other NADPH oxidase complex subunits that encode gp91phox, p47phox, p67phox, and p22phox or of the transmembrane membrane chaperone, EROS, exhibit loss of PMA-induced ROS production (60–62). This evidence concerns the gene CYBA and chronic granulomatous disease.