By contrast, neutrophils from patients with CGD caused by genetic deficiency of any of the other NADPH oxidase complex subunits that encode gp91phox, p47phox, p67phox, and p22phox or of the transmembrane membrane chaperone, EROS, exhibit loss of PMA-induced ROS production (60–62). Here, NCF1 is linked to chronic granulomatous disease.