DNMT3A and acute myeloid leukemia: Hence, several epi-mutations are commonly found in FLT3-ITD AML, including the gene mutations in histone modification Enhancer of Zeste Homologue 2 (EZH2) and the additional sex combs-like gene (ASXL1), regulation of DNA methylation (DNMT3A, TET2), and enzymes regulating metabolism (IDH1/2) with epigenetic consequences [14, 17].