FLT3 and acute myeloid leukemia: Hu and colleagues showed that decitabine, as a single agent, on MV4-11 and MOLM-13 FLT3-ITD AML cells, induced C/EBP alpha-PU.1 pathway, which is required for myeloid differentiation, leading to downregulation of FLT3 and induction of apoptosis.