The peripheral white blood cell count is significantly higher in DNMT3A/FLT3-ITD co-mutated AML patients compared to FLT3-ITD AML patients and DNMT3A/FLT3-ITD mutations results in higher burden of disease compared to only DNMT3A-mutated AML patients [190, 191]. Here, FLT3 is linked to acute myeloid leukemia.