A series of Rab GTPases such as Rab1, Rab3, Rab8, Rab25, Rab27 and others (as summarized in Table 2) promote cancer cells migration and invasion to exert critical infuences on tumor progression through mediating intracellular signaling pathways (Tzeng and Wang 2016). The gene discussed is RAB1A; the disease is neoplasm.