Moreover, Rapamycin, the mTOR inhibitor, is proved to effectively suppress Rab22a-triggered proliferation, migration and invasion in lung adenocarcinoma cells, indicating that Rab22a regulates the biological malignancies of lung adenocarcinoma cells through activating PI3K/AKT/mTOR signaling (Wang et al. 2022). This evidence concerns the gene AKT1 and lung adenocarcinoma.