Mechanically, PathScan results showed the decreased phosphorylation levels of the RTK family members (including InsR, Met/HGFR, Ron/MST1R, Ret) and elevated phosphorylation levels of stress and apoptosis family members (including HSP27, p38 MAPK and TAK1), indicating that inhibition of RTK pathways and activation of stress and apoptosis might be responsible for Rab10 modulation of HCC cell growth and apoptosis (Wang et al. 2017). This evidence concerns the gene MET and hepatocellular carcinoma.