We found a 1.6-fold increase in p16 positive microglia with AD compared to NDC (p value = 0.01) (Fig. 1b, Supplementary Fig. 1a–c) but no significant differences between numbers of p16 positive oligodendrocytes (1.1-fold, p value = 0.32) or astrocytes (1.3-fold, p value = 0.31) were found. Here, CDKN2A is linked to Alzheimer disease.