The fraction of Micro1 nuclei enriched for CSP gene sets in AD was greater than in control tissue (Fig. 5f, Wilcoxon rank-sum, p value < 0.01) and this fraction increased in Micro1 nuclei in proportion to the tissue β-amyloid loads (Fig. 5g, Pearson’s correlation R = 0.34, p value = 0.021). This evidence concerns the gene DNAJC5 and Alzheimer disease.