It was additionally found that mutations in Hedgehog signaling pathway genes (SMO, PRKAR1A, SUFU) in CNS WHO grade 1 meningiomas were associated with increased risk of postoperative seizures.282 Additional work is needed to ascertain whether specific molecular alterations can independently predict perioperative seizure risk or if the postoperative course is mainly affected by the anatomic location associated with meningiomas harboring SMO, PRKAR1A, or SUFU mutations. This evidence concerns the gene SMO and meningioma.