TERT and cancer: Finally, mutations in the TERT (telomerase reverse transcriptase) promoter (TERTp) have been added to the most recent iteration of the WHO classification as an independent marker of grade 3 meningiomas.3 While rare in meningiomas, this alteration is associated with significantly worse progression-free survival (PFS) and overall survival when present.55,56TERT functions to maintain DNA telomere ends, resulting in immortalization of cancer cells.