Heritable genetic polymorphisms in MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) have also been robustly associated with increased meningioma risk.7,8 Distinct from germline variants that cause hereditary syndromes associated with meningiomas, MLLT10 risk alleles are common at the population level and confer a comparatively modest increase in meningioma risk. This evidence concerns the gene MLLT10 and meningioma.