NF2 and meningioma: RIMs have a much higher burden of cytogenetic changes compared to sporadic meningiomas including frequent losses of chromosomes 1p (over 50% of cases), 9p, 19q, 18q, 10p, and 22q.10,14,319 Notably, RIMs were less frequently found to have loss of chromosome 22q or NF2 point mutations compared to sporadic meningiomas but had more frequent NF2 gene fusion events.