ACHE and early-onset autosomal dominant Alzheimer disease: With respect to human AChE inhibitory activity, there is increasing interest in the application of AChE in preventing and treating Alzheimer disease (Khan et al., 2009; Mani et al., 2023) and, more recently, in the application of AChE from arthropods due to the resistance phenomena among diverse tick infestations, such as R. microplus.