Specifically, EEA1 (early endosome antigen 1), RAB3, RAB7 (endosomal proteins), LAMP1 (lysosomal associated membrane protein 1) and LAMP2 (lysosomal proteins), LC3 (a marker of autophagosomes) and LAMP2 (a marker of AVs) were significantly higher in CSF of AD patients than in controls [28,29]. Here, EEA1 is linked to Alzheimer disease.