In contrast, serum levels of TFEB were significantly lower in AD dementia individuals (670.1 ± 368.6 pg/mL) than in MCI-AD (744.3 ± 351.9 pg/mL) (p = 0.033) and CU (966.5 ± 1562.5 pg/mL) (p = 0.040) (F [2] = 6.20, p = 0.002, η2 = 0.04) (Figure 1D). Here, TFEB is linked to Alzheimer disease.