This study reveals that mitophagy activators PINK1 in CSF and serum and BNIP3L in serum are higher in AD dementia individuals than in MCI-AD and CU controls, while serum TFEB, a master regulatory of lysosomal biogenesis, is lower in AD dementia than in MCI-AD individuals and CU controls independently of APOE status or levels of neurodegeneration. The gene discussed is PINK1; the disease is Alzheimer disease.