LEPR and Glucose intolerance: In a model of glucose intolerance that mimics a milder hyperglycemia associated with insulin resistance and the absence of intrauterine growth restriction (101), offspring of leptin receptor deficient mice (Leprdb/+), which spontaneously develop glucose intolerance during gestation, showed an early nephron deficit with glomerular hypertrophy at 6 mo, although renal function was normal.