Meanwhile, there is mounting evidence that the immunological milieu of vitiligo is also characterized by cytokines connected to other Th2 cell responses, such as IL-4, IL-5, IL-10, IL-13, and IL-31, rather than just Th1 cells and related cytokines (IFN-γ, TNF-α, and IL-2) (25, 35, 54). Here, IL31 is linked to vitiligo.