MAPK8 and ovarian carcinoma: Since activated JNK phosphorylates MFN2, causing it to be degraded via the ubiquitin-proteasome system, the expression of MFN2 can be restored after supplementation with hydrogen sulfide or glutathione, antioxidants, or JNK inhibitors, and the improvement of mitochondrial morphology contributes to cell proliferation in ovarian cancer (113).