Specifically, IP3R1 has been identified as a central player in the development of cardiac hypertrophy (Nakayama et al., 2010; Garcia et al., 2017), while IP3R1 in vascular smooth muscle cells (VSMCs) has been shown to contribute to peripheral vasoconstriction during HF (Dridi et al., 2022). The gene discussed is ITPR1; the disease is hydrops fetalis.