For the anti-inflammatory activities, it was found that linarin competitively bond to MD2, inhibited the formation of TLR4/MD-2 dimer, downregulated the increase of TRAF-6, IRAK-1 and MyD88, reduced the nuclear transfer of NF-κB (P65), TNF-α, IL-6, NO, PGE2, and decreased the synthesis of COX-2 and iNOS, suggesting that linarin might reduce the inflammation of chondrocytes by occupying the binding site of MD2 to improve the progression of arthritis in mice (Qi, 2021). Here, TRAF6 is linked to arthritic joint disease.