TNF and metabolic dysfunction-associated steatotic liver disease: Through network pharmacology and experimental verification, Xu et al. (Xu, et al., 2021) found that saffron contains a total of 206 key components, including crocetin (CCT), and also contains 6 cross-targets, mainly AKT1, MAPK1, and STAT3, etc., while the AGE-RAGE signaling pathway in diabetic complications, HIF-1, TNF, and other diabetes-related signaling pathways are the main signaling pathways involved in the therapeutic effects of saffron on NAFLD.