NFKB1 and metabolic dysfunction-associated steatotic liver disease: At the same time, in vitro studies have also found that POF can effectively activate the AMPK signaling pathway, inhibit the NF-κB signaling pathway, relieve free fatty acid-induced inflammation, oxidative stress, steatosis, mitochondrial dysfunction, etc., and finally confirm that POF can be used as a special key therapy for NAFLD.