Previous research demonstrates that CAFs can modulate the extracellular matrix (ECM) by producing collagen, fibronectin, laminin, and MMPs, thereby creating a conducive microenvironment for EMT in tumor cells, thereby endowing them with VM capabilities (Seftor et al., 2001; Yang et al., 2016; Poltavets et al., 2018). This evidence concerns the gene LAMB2 and neoplasm.