Cancer hallmarks such as P53 signaling, glycolysis, KRAS signaling pathways, and immune-related pathways such as TNF-α, TGF-β, IL2/STAT5, IL-6/JAK/STAT3, interferon-γ response, and inflammatory response pathways were also positively associated with VM (Figures 2B,C). This evidence concerns the gene TP53 and cancer.