The results showed that AC can improve the memory and learning abilities by inhibiting several AD risk factors, including reactive oxygen species (ROS), p-tau, and BACE expression, as well as Aβ1-40 accumulation, suggesting that the fruiting body has stronger anti-oxidant and anti-inflammatory abilities to inhibit Aβ1-40-induced neurotoxicity than the mycelium. Here, MAPT is linked to Alzheimer disease.