To further explore the correlation between BMI and PLOD2, metabolic factors associated with obesity were analyzed for their correlation with PLOD2. In the univariate analyses, significant correlations with PLOD2 expression were found for lean mass, (r2 ​= ​0.20, P ​= ​0.002), fat mass (r2 ​= ​0.20, P ​= ​0.001), serum TC (r2 ​= ​0.17, P ​= ​0.004), serum TGLY (r2 ​= ​0.19, P ​= ​0.003), and serum leptin (r2 ​= ​0.10, P ​= ​0.03). Here, PLOD2 is linked to obesity due to melanocortin 4 receptor deficiency.