AML cells secrete various factors that impair T-cell function and promote apoptosis, express inhibitory ligands like programmed death receptor 1 (PD-L1) or T cell immunoglobulin and mucin-containing-3 (TIM-3), and downregulate the expression of MHC molecules, impairing their antigen presentation to the immune cells and resulting in immune evasion (Mardiana and Gill, 2020). This evidence concerns the gene HLA-C and acute myeloid leukemia.