AML cells secrete various factors that impair T-cell function and promote apoptosis, express inhibitory ligands like programmed death receptor 1 (PD-L1) or T cell immunoglobulin and mucin-containing-3 (TIM-3), and downregulate the expression of MHC molecules, impairing their antigen presentation to the immune cells and resulting in immune evasion (Mardiana and Gill, 2020). The gene discussed is CD274; the disease is acute myeloid leukemia.