HAVCR2 and acute myeloid leukemia: In spite of this, the overexpression of exhaustion markers on AML blasts makes them an interesting target for CAR-T cell therapy, and some groups are developing anti-TIM3 CAR-T cells with high cytotoxicity against AML cell lines and patient-derived AML samples in vitro and in murine models (He et al., 2020; Lee et al., 2021).