When the Wnt/β-catenin pathway was activated in CRC, the expression of CAF-derived exosomal miR-92a-3p rose and directly suppressed FBXW7 and MOAP1 expression to prevent mitochondrial apoptosis, causing CRC cells to produce stem cell characteristics (Hu et al., 2019). The gene discussed is MOAP1; the disease is colorectal carcinoma.