miRNAs in the DLK1-DIO3 imprinting area, including miR-329-3p, miR-380-3p, miR-410-5p, and miR-431-5p, were found to be upregulated in hepatocellular carcinoma (HCC) cells co-cultured with exosomes produced from CAFs. Here, DLK1 is linked to hepatocellular carcinoma.