Furthermore, TLR3/TLR4-TRIF exerts a crucial antiviral role in the initial stage of viral hepatitis, and when viral hepatitis progresses to serious complications such as cirrhosis and hepatocellular carcinoma, TLR3/TLR4-TRIF has been found to accelerate the disease process. This evidence concerns the gene TICAM1 and hepatocellular carcinoma.