TMPRSS2 and cystic fibrosis: There is a z report of a decreased level of TMPRSS2 among CF patients compared to the control group, although it was not significant, and there is also an increase in the TMPRSS2 enzyme in CF patients by flagellin of Pseudomonas aeruginosa (Bitossi et al., 2021; Ruffin et al., 2021).