Also in pancreatic cancer, Zou et al. described the expression of the receptors for the estrogen receptors alpha and estrogen receptors beta in pancreatic adenocarcinoma as a positive prognostic factor, noting that, where estrogen receptors are expressed, infiltration with CD8+ T lymphocytes increases, as does the number of TLSs, suggesting the remodeling of the immune microenvironment as well as the simulation of the development of TLS. The gene discussed is ESR1; the disease is familial pancreatic carcinoma.