Also in pancreatic cancer, Zou et al. described the expression of the receptors for the estrogen receptors alpha and estrogen receptors beta in pancreatic adenocarcinoma as a positive prognostic factor, noting that, where estrogen receptors are expressed, infiltration with CD8+ T lymphocytes increases, as does the number of TLSs, suggesting the remodeling of the immune microenvironment as well as the simulation of the development of TLS. This evidence concerns the gene ESR2 and familial pancreatic carcinoma.