This AI-assisted DP-immune assay has revealed the prognostic impact of the immune response in CC patients to improve treatment decision-making in early stages,32–34,50–52 In a study comparing immune response assessment in CC using IS (automated DP) and pathologist visual scoring (T-score), four pathologists evaluated tumor specimens from 50 early-stage CC patients and classified CD3+ and CD8+ stained slides.51 While digital pathology IS proved highly reproducible,34 agreement among pathologists was minimal to weak. Here, CD8A is linked to neoplasm.