Techniques such as radiolabelled anti-CD8 imaging and radiomics-based AI provide valuable insights into the immune microenvironment and enable the extraction of quantitative features from medical images, enhancing the ability to comprehensively understand tumor heterogeneity.98 These innovative approaches not only could guide clinicians toward more effective and targeted interventions in precision medicine but also highlight the importance of addressing the limitations of traditional biopsy methods. Here, CD8A is linked to neoplasm.