Administration of Kencur ethanol extract at a dose of 1,200 mg/kgBW/day for 48 hours is better than a dose of 600 mg/kgBW/day given for 24 h and 48 h or a dose of 1,200 mg/kgBW/day only given for 24 h in suppressing cerebral caspase-3 expression in rats that experienced traumatic brain injury. The gene discussed is CASP3; the disease is brain injury.