Recent advances in pathological diagnosis using IHC have made the identification of the primary site of metastatic liver lesions possible in many cases with CK7 and CK20 staining and disease‐specific markers: hepatocyte, AFP (hepatocellular carcinoma), CDX‐2 (colorectal cancer), ER, PR (breast cancer), PSA (prostate cancer), and GATA‐3 (urothelial carcinoma).22, 23, 24, 25. The gene discussed is AFP; the disease is breast cancer.