CCL2 and COVID-19: However, in a recessive model, the GG genotype of the CCL2 rs1024611 gene variant showed a significant association with the severe clinical manifestation of COVID-19 (P<0.0001, OR = 5.71, 95% CI 2.38-13.70), while in an overdominant model, the AA genotype showed a protective effect against the severe clinical phenotype of (P=0.0044, OR = 0.30, 95% CI 0.13-0.71).