In addition, we found that the CCL2 rs1024611-G allele had a significantly higher frequency in the case group after adjustment for age (<50 and ≥50 years), sex, obesity (BMI ≥30), and comorbidities, and rs1024611-G was found to be associated with the severe phenotype of COVID-19 in a recessive genetic model. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.