The top 10 significantly enriched KEGG pathways are shown in Supplementary Figure S2B, which mainly involved Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Protein digestion and absorption, PI3K-Akt signaling pathway, ECM-receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, IL-17 signaling pathway, Breast cancer and Gastric cancer. The gene discussed is PIK3CA; the disease is breast cancer.