To further explore whether the combination of dictamnine with LEP, NGF and PCOLCE2 could exert anti-tumor effects, we performed molecular docking of dictamnine with LEP, NGF and PCOLCE2, and the predicted results indicated that dictamnine could access the potential binding pocket of LEP, NGF and PCOLCE2 (Figure 7A). This evidence concerns the gene PCOLCE2 and neoplasm.