Further, they investigated the anti-tumor effect of NK-92/9.28.z cells in vivo using NOD/SCID mice with subcutaneous SK-HEP-1 and SK-HEP-1/GPC3 xenografts.The introduction of NK-92/9.28.z cells significantly suppressed the growth of the SK-HEP-1/GPC3 xenografts but had no impact on the growth of the SK-HEP-1 tumors. The gene discussed is GPC3; the disease is neoplasm.