The engineered NK-92/9.28.z cells demonstrated cytotoxicity effects against GPC3-positive HCC cell lines, including HepG2, Huh-7, Hep3B, and PLC/PRF/5, while sparing GPC3-negative cells and showing no impact on GPC3- SK-HEP-1 and SMMC-7721 cells (157). Here, GPC3 is linked to hepatocellular carcinoma.