In the pursuit of concurrently targeting GBM antigens (CD73, GD2, and NKG2DL), the researchers constructed a bicistronic vector expressing two distinct CARs: a GD2.CD28.CD3ζ-CAR and an NKG2D.DAP10.CD3ζ-CAR in NK cells. This evidence concerns the gene NT5E and glioblastoma.