The results showed an increase in therapeutic signatures, such as base excision repair, cell cycle, the Fanconi anemia pathway, DNA replication, miRNA in cancer, nucleotide excision and mismatch repair, homologous recombination, the p53 signaling pathway, oocyte meiosis, oocyte maturation mediated by progesterone, pyrimidine metabolism, proteasome, spliceosomes, antiviral carcinogenesis in patients in C3 compared to C1 and C2 (Figure 3A). Here, TP53 is linked to cancer.