Atraric acid, a natural AR antagonist, suppresses proliferation and induces senescence in PCa cells—both androgen-dependent (LNCaP) and castration-resistant (C4-2), as well as in PCa-like tumors from prostatectomies via the p16INK4a-pRb-E2F1 CyclinD1signaling pathway (87). Here, RB1 is linked to posterior cortical atrophy.