The overexpression of folate receptor alpha in the majority of ovarian malignancies have led to the development of anti-folate receptor alpha SPIONs that can reliably detect ovarian tumors.151 Lung tumors can also be visualised by taking advantage of the overexpressed folate receptor, as Kimura et al.152 showed by using polyethylene glycol-coated and dextran-coated SPIONs. This evidence concerns the gene FOLR1 and ovarian neoplasm.