Indeed, proteins involved in CME such as AP180 (cargo selection), AP-2 (cargo selection/clathrin recruitment), and Dynamin 1 (scission) are shown to be decreased in AD in various regions of human post-mortem brains at both the RNA and protein level (Yao et al., 1999, 2000, 2003; Cao et al., 2010; Piras et al., 2019). The gene discussed is SNAP91; the disease is Alzheimer disease.