Importantly, while not directly involved in CME, many other significant AD risk factors like Apolipoprotein E (APOE), Ras and rab interactor 1 (RIN1), and Sortilin related receptor 1 (SORL1) have been related to endosomal and lysosomal dysfunction downstream from CME and are reviewed elsewhere (Szabo et al., 2022; Maninger et al., 2024). This evidence concerns the gene APOE and Alzheimer disease.