In Alzheimer’s disease (AD), genetic links have been made to endocytic protein genes such as AP-2 (cargo selection), Clusterin (CLU, cargo selection), Bridging integrator 1 (BIN1, scission), CD2 associated protein (CD2AP, scission/uncoating), and Phosphatidylinositol binding clathrin assembly protein (PICALM, cargo selection) (Raj et al., 2018; Azarnia et al., 2019; Ando et al., 2022; Szabo et al., 2022). This evidence concerns the gene PICALM and early-onset autosomal dominant Alzheimer disease.