MAPT and Classical progressive supranuclear palsy: One study applied brain derived Tau oligomers from human post-mortem tissue of tauopathies including AD, progressive supranuclear palsy, and dementia with Lewy bodies to mouse primary neurons and showed that Tau oligomers from each disease state were internalized via the same non-Dynamin dependent endocytic mechanisms (Puangmalai et al., 2020).