GRAMD1C and hyperinsulinemic hypoglycemia, familial, 4: These data show that, particularly under low dietary cholesterol conditions, Gramd1c deficiency is associated with reduced expression of several genes involved in xenobiotic metabolism (Cyp3a41a, Cyp3a41b, Cyp3a44, Cyp3a16, and Sult3a2) as well as increased expression of major urinary protein genes (Mup7, Mup11, Mup12, and Mup20) that encode lipid-binding proteins within the lipocalin family.