HCRT and Cataplexy: It should also be noted that only SOREM sleep-like behavior, but not other kinds of disrupted timing such as cataplexy, occurs in the orexinSLD-caspase mice, even at the high REM sleep need condition, indicating that additional influences on the occurrence of cataplexy from other players may exist, such as the lack of orexin’s direct modulation on central motor excitation [36,51–53].