In summary, our study is the first to show that remodeling the gut microbiota with intermittent antibiotic treatment and subsequent transfer via cohousing, and supplementing with beneficial microbial metabolites effectively alleviate NASH and atherosclerosis in both HFHC and HC diet-fed LDLR-/- hamster models, closely resembling CHL patient characteristics. The gene discussed is LDLR; the disease is classic Hodgkin lymphoma.