Previous studies with a small sample size had demonstrated that diabetes patients who were either insulin-dependent or insulin-independent had a lower pancreas volume than healthy controls.11, 12, 13Additionally, it was discovered that patients with type 1 diabetes or young patients with maturity-onset diabetes had smaller pancreatic volumes than controls or T2DM patients.14These findings imply that impaired insulin secretion is linked to decreased pancreatic volume. The gene discussed is INS; the disease is diabetes mellitus.