Numerous studies have established an overall detrimental role of IL-1R1 in kidney injury, as global genetic deletion of IL-1R1 reduces AKI and/or kidney fibrosis following I/R (Haq et al., 1998), unilateral ureteral obstruction (Jones et al., 2009), cyst formation (Yang et al., 2019), and cisplatin AKI (Privratsky et al., 2018). The gene discussed is IL1R1; the disease is Ureteral obstruction.