PITX2 and cancer: Recently, more and more studies have shown that RGS family genes, as regulators of GPCRs, play an important role in the occurrence, development and prognosis of many cancers and has been proved to be potential drug targets for the treatment of malignant tumors (Hurst and Hooks, 2009; Dasgupta et al., 2021; Weisshaar et al., 2022; Zhang et al., 2022).